switched from semaglutide to tirzepatide Maintenance therapy on or Switching Semaglutide to Tirzepatide |

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The SELECT cardiovascular outcomes trial published in 2023 added a cardiovascular benefit signal: semaglutide reduced major adverse cardiovascular events by 20% in overweight and obese patients with established cardiovascular disease, independent of diabetes status

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NHS-approved alternatives include orlistat, semaglutide (Wegovy), and liraglutide (Saxenda), all available under appropriate clinical supervision