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Mechanistic studies have shown that oxidative stress further upregulates 5-LOX expression by activating the Nrf2 signaling pathway, forming a vicious cycle of oxidative stress-lipid peroxidation, which leads to impaired humoral immune function and the expansion of myeloid-derived suppressor cells (MDSCs), thereby promoting tumor immune escape (160)

As with any supplement, L-carnitine is not a cure-all