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Research indicates that puerarin enhances antioxidant defense by regulating ferritin, activates the Nrf2 signaling pathway through upregulation of GPX4 and SLC7A11, and effectively alleviates iron overload and lipid peroxidation in heart failure models, thereby protecting cardiomyocytes from damage [228]

Figure 1 2.2 Determination of the instrumental variables Instrumental variables (IVs) are characterized by three pivotal assumptions: (1) Association assumption: There exists a robust correlation between SNPs and exposure factors

Adult hippocampal neurogenesis poststroke: more new granule cells but aberrant morphology and impaired spatial memory