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GLP-1RAs improve metabolic health and this can be particularly helpful in bipolar disorder as patients often have a higher risk of metabolic syndrome

Metabolic clearance of corticosteroids is decreased in hypothyroid patients and increased in hyperthyroid patients

Adipose tissue is divided into WAT with a small number of mitochondria in the cell and BAT with a large number of mitochondria in the cell

A dual GLP-1-estrogen conjugate (GE) designed to selectively deliver estrogen to GLP-1R + cells induced substantial weight loss in mice without evidence of systemic estrogenic effects, as assessed by uterine weight and growth of estrogen-dependent breast cancer xenografts ( In another preclinical study, GE demonstrated superior metabolic effects compared to GLP-1-GIP or GLP-1-GIP-glucagon multiagonist therapies in models of polycystic ovary syndrome (PCOS), a condition frequently associated with obesity and insulin resistance