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They team up to keep cells healthy, support energy production, and protect against oxidative damage

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Collectively, this dual metabolic identity, preserving physiological specialization in citrate production while hijacking polyamine and citrate pathways for oncogenic rewiring, not only distinguishes PCa from other malignancies but also unveils targetable vulnerabilities for diagnostic and therapeutic innovation

In addition to cytochrome-C/caspase-3-mediated apoptosis, there is growing evidence for caspase-independent pathways in programmed cell death