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Autophagy 12(4):7056 Wilson AG (2008) Epigenetic regulation of gene expression in the inflammatory response and relevance to common diseases

Although many enzymes in one-carbon metabolism are affected by the sex hormones testosterone and estradiol, the main reasons for sexual dimorphism in glutathione metabolism are the effects of estradiol and the GSH regulatory motif, which includes the inhibition of GS and GCL by GSH itself [Figure 2B]

However, it is important to have realistic expectations and understand the facts surrounding its use

Preclinical data does indeed suggest that axonal projections to the visual cortex release the excitatory neurotransmitter glutamate, which lower the threshold for CSD initiation [43,44,45]