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A recent study demonstrated that rosiglitazone protects islet beta cells against palmitate-induced cell death by activating autophagy through activation of AMPK and subsequent inhibition of the mammalian target of rapamycin (mTOR) signaling pathway 30

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Among these trials, one involving 36 patients with T2DM did not show any difference from baseline on the MMSE and MoCA after liraglutide at 16 weeksalthough all participants had preserved cognitive function at baseline, while an improvement on tests for delayed memory (possibly mediated by left hippocampal activation), attention and executive function was noted 42