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Glutathione is an important molecule in the detoxification process

That metallothioneins are the main factor contributing to cadmium protection in SLC30A1 -KO cells is also supported by the observation that inactivation of SLC30A1 conferred a weaker protective effect against mercury toxicity, because metallothioneins have a weaker affinity to mercury, potentially due to prior conjugation of mercury to glutathione (Tokumoto et al, 2018)