In 5xFAD mice, selective neuronal loss is found in cortical layer 5 (L5), without affecting the overall neuron number in the total frontal cortex and hippocampus, and this correlates with the reduced anxiety-like behavior (Vrkonyi et al., 2022)
Glutathione plays a critical role in reducing oxidative stress and supporting liver function, but levels can decline due to aging, stress, and environmental exposure
In specific embodiments, any formulation or composition described herein has a pH that allows for terminal sterilization (e.g., by heat treatment and/or autoclaving) of a formulation or composition without degradation of the therapeutic agent
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