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No published trials directly compare berberine alone to semaglutide or tirzepatide, and no large studies have tested the combination in humans, leaving the synergy question open

127138, Berg, Alison C., et al

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For behavioral evaluation, all experimental animals were transported to a behavioral room at least 1 hour before the commencement of experiments and the environment was kept very calm (with balanced light, visuals and adequate room temperature)