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As reported by Medical Brief, the lawsuits claim the company failed to adequately warn patients of the risk of permanent blindness

Sodium hydrogen exchange regulator (NHERF) protein, which is abundantly expressed in the apical membrane transported by epithelial cells, such as renal proximal tubules and small intestine, interacts with mURAT1 and plays an important role in the regulation of uric acid transport in renal proximal tubule cells (Hosoyamada et al., 2004

As your body adjusts to treatment, some side effects may occur, particularly during the first few weeks or following a dose increase

Future trials or post-marketing data will need to establish whether retatrutide allows dose reduction for maintenance without significant weight regain