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64 Far more research has been done with NAC, with several reviews citing the therapeutic value of NAC in treating psychiatric and neurological disorders, including but not limited to ASD, addictions, obsessivecompulsive disorder, and Alzheimers disease

Disruption of clock genes: desynchrony at the molecular level The SCN, as the master circadian clock, derives its rhythm from a transcription-translation feedback loops (TTFLs) driven by a series of clock genes (e.g., CLOCK , BMAL1 , Per , Cry ) (80)

Additionally, our findings on glutathione antioxidant pathway suggest ozone therapy up regulated the antioxidant defense system counteracting the oxidative stress produced from the inflammatory mediators