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A more clinically relevant consideration involves metabolic and hormonal interplay : Significant weight loss induced by retatrutide may alter sex hormone-binding globulin (SHBG) levels, which in turn affects the ratio of free to total testosterone

[5] ^ Terashima, Tomoya, Hideto Kojima, Hiroshi Urabe, Isamu Yamakawa, Nobuhiro Ogawa, Hiromichi Kawai, Lawrence Chan, and Hiroshi Maegawa

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Yellowing of the skin If you notice that your skin is starting to look yellow, it could be a sign of a vitamin B12 deficiency