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Targeting Wnt/-catenin and BCL-2, Two Critical Survival Factors, Synergistically Induces Apoptosis in AML via Rac1-mediated MCL-1 inhibition

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As a major cell type in kidney, proximal tubular cell produce ATP via fatty acid -oxidation (FAO) in mitochondria ( via controlling the transcription and translation of FAO-related enzymes (Xu et al., 2022), which could further trigger the impairment of mitochondrial structure and function ( 3 Natural products for regulating mitochondrial function 3.1 Enhancing mitochondrial biogenesis and energetics It is widely found that impaired mitochondrial biogenesis and energetics contribute to the pathogenesis of kidney diseases (Weinberg, 2011

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