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JAMA Cardiol 2(12):13151321 Arnold SV, Stone GW, Mack MJ, Chhatriwalla AK, Austin BA, Zhang Z et al (2020) Health status changes and outcomes in patients with heart failure and mitral regurgitation: COAPT Trial

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By stripping the molecule down to its terminal three residues, researchers hoped to keep the anti-inflammatory tail while discarding the receptor-driven pigmentation and the colitis data suggest that at least some of KPVs activity runs through a receptor-independent, transporter-mediated route rather than classic melanocortin signaling