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Analyses were also performed with these two subjects excluded completely, and this did not change the results

It first received FDA approval in the late nineties, and although it has demonstrated effectiveness for some people, newer medications specifically designed for weight management are now available

This raises questions about the relative therapeutic importance of maintaining an adequate pool of surface GLP-1Rs during prolonged stimulations versus aiming for maximal endosomal receptor activation

Severe or prolonged side effects should be reported to the prescribing physician immediately for further evaluation and discussion about potential alternatives.