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Plasminogen is converted to plasmin by tissue plasminogen activator (TPA)

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By increasing free iron through ferritin autophagy, a selective autophagy mechanism that targets ferritin, ferritin might encourage ferroptosis ( 3.1.2 ROS imbalance plays an important role in ferroptosis Lipid peroxidation is the fundamental root cause of ferroptosis, and since lipids make up the majority of cell membranes, they are also the dominating targets of ROS