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This trade-off is consistent with in human evidence that sustained energetic stress can lead to progressive myelin loss even in the absence of overt axonal pathology (Ramos-Cabrer et al., 2025), suggesting that metabolic compensation may preserve short-term function at the expense of long-term myelin integrity

325,326 In HD, HSP27 exerts neuroprotective effects by suppressing polyglutamine toxicity and lowering ROS levels, thereby slowing neurodegenerative progression

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Kinoshita, S., Hosomi, K., Yokoyama, S