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On the other hand, GLP-1R signaling in astrocytes was proven to be essential for maintaining mitochondrial integrity and function of the hypothalamic astrocytes, as deletion of GLP-1Rs resulted in the adaptive cellular stress response with the improvement of glucose metabolism and memory formation [97]

Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS

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On the other hand, cyclization of the 3-chloroacetamide restored activity (cluster-5)