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Definitive conclusions about long-term cardiovascular effects await the completion of ongoing outcomes trials

Regarding other endpoints, which have mainly been focused on cardiovascular risk markers, the overall effect of the naltrexone/bupropion combination has been positive over lipid profile and insulin resistance

The improvement in pharmacokinetics helped prevent the negative gastrointestinal side effects typical of GLP- 1-based selective agonists by reducing maximum drug exposure and reducing reliance on GLP- 1-mediated pharmacology

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