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However, injectable semaglutide still delivers greater weight loss and is the only anti-obesity medication with proven cardiovascular benefit

One may argue that with extended half-life, therapeutic agents GLP-1RAs are resistant to DPP-4 mediated degradation, allowing them to reach to the brain to exert their anorexic and other brain functions directly

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For those interested in how semaglutide intersects with fitness-related body composition goals, the guide on losing weight on semaglutide without exercise and the broader discussion of how fast weight loss progresses are useful for setting expectations