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Melatonin stimulates key antioxidant enzymes like SOD, GPx and GR, protecting cells from lipid peroxidation and neutralizing harmful radicals

Photodegradation, the breakdown of molecular structures by light energy, can cleave peptide bonds over time

Most common side effects (12mg dose, across TRIUMPH-4 and TRIUMPH-1): Nausea: 43% TRIUMPH-4 / ~38% TRIUMPH-1 (mostly during dose escalation) Diarrhea: 33% / ~28% (peaks weeks 48, improves by week 16) Dysesthesia: 20.9% (tingling sensations onset variable, long-term persistence unknown) Vomiting: 21% / ~25% (decreases after month 3) Constipation: 25% Discontinuation rates: 18.2% in TRIUMPH-4 (osteoarthritis population), 11.3% in TRIUMPH-1 (general obesity population)

compounding pharmacies and prescribed only when a commercially available option is not appropriate for a specific patients medical needs