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Current evidence suggests that while GLP-1 agents clearly affect gastric emptying as part of their mechanism, progression to clinically significant, persistent gastroparesis appears uncommon

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In the short-term placebo-controlled trial in adults with schizophrenia, there were no patients in either treatment group with a significant orthostatic change in blood pressure (defined as a decrease in systolic blood pressure 20 mmHg accompanied by an increase in heart rate 25 bpm when comparing standing to supine values)