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Distinguishing GLP-1 Side Effects from Illness Nausea : GLP-1-related nausea typically: Appears within a few hours of injection Improves with time and regular eating patterns Is mild to moderate in severity Doesnt include vomiting (usually) Illness-related nausea often: Comes with other symptoms (fever, congestion, body aches) May include vomiting Can be more severe and persistent Doesnt follow your injection schedule Fatigue : GLP-1 medications can cause mild tiredness, especially when starting or increasing doses