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Safety data confirm that GLP-1RAs and TZP increase the risk of gastrointestinal adverse events (mostly mild-to-moderate), including nausea, diarrhea, and vomiting that are usually well-tolerated and resolved in a few weeks of treatment because of tachyphylaxis (especially with long-acting analogues and TZP)
Setting weight loss as the standard for success does not address other potential measures of success, such as improved metabolic markers (blood sugar, cholesterol), lifestyle, mental health, and activities of daily living
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By linking mechanistic insights with emerging imaging and multi-omics technologies, this review highlights a path toward biomarker-driven patient stratification and precision cardiovascular therapeutics, redefining how vascular risk is assessed and treated in metabolic disease
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