23andme semaglutide If you aren't losing weight with GLP-1s, this may be one reason why Some people lose over 20%

Although the serotonergic pathway may create a physiological decrease in sexual desire for patients taking GLP-1 agonists, we postulate that this diminishing influence of GLP-1 agonism is both compounded by factors such as undesirable side effects and increased SHBG and offset by the enhancing influences on sexual desire such as increased total testosterone, and improved vascular reactivity and mood

This signals to your brain that starvation is not imminent, reducing some of the metabolic slowdown

This is more helpful for diabetes but can also help with weight management as unmanaged blood sugar can cause cravings

And if your kidneys arent functioning properly, they cant filter out sodium as well