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However, these compounds are associated with Nrf-2-independent adverse effects, which prevented their clinical use despite their beneficial induction of glutathione synthesis

Despite these findings of higher total and unbound prednisolone concentrations, elderly subjects had higher AUCs of cortisol, suggesting that the elderly population is less sensitive to suppression of endogenous cortisol or their capacity for hepatic inactivation of cortisol is diminished

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Tube 0 (Reagent Blank): This tube should contain only 100 L of Standard Diluent to serve as the zero concentration point