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Intestinal inflammation and consequent systemic inflammation Cytokines and chemokines are crucial for intercellular communication and contribute to maintain intestinal homeostasis through inflammatory mechanisms, but when these are constantly elevated, epithelial barrier integrity results compromised [119]

P values indicated, calculated by two-tailed t -test ( a,b,d ) or one-way ANOVA with Dunnetts multiple comparisons test ( g,i )

113,114 Current treatments are only partially effective, and further understanding of the diseases mechanism are needed to develop effective drugs

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