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The weight loss is driven primarily by the drug's metabolic and appetite-regulating effects, not by making people feel sick

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c , Comparison of TT-OAD2-bound GLP-1R with the small peptide HepP5-bound GLP-1R structure

Discontinuation should be considered when: Vomiting is severe, persistent, and unresponsive to management strategies Symptoms significantly impair quality of life or ability to function Dehydration or malnutrition develops Complications such as pancreatitis are suspected or confirmed (Ozempic should not be restarted if pancreatitis is confirmed) [1] [2] The patient wishes to discontinue despite medical advice to continue Alternative GLP-1 receptor agonists with different pharmacokinetic profiles may be better tolerated if Ozempic is discontinued