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In BV2 microglial cells, BV2-metformin-loaded PLGA treatment downregulated inducible nitric oxide synthase (iNOS) expression (proinflammatory M1 phenotype) and upregulated mannose receptor (CD206) expression (anti-inflammatory M2 phenotype), leading to a more than three-fold elevation in the CD206/iNOS fluorescence intensity ratio

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Thus, T reg cells expressing Foxp3 are crucial in limiting intestinal inflammatory responses ( + Foxp3 + CD4 + T reg cells and reduced the number of IL17A + CD4 + T-helper (Th)17 cells, thereby modulating T cell responses and suppressing intestinal inflammatory responses ( + Foxp3 + T reg cells ( reg cells ( Histone acetyltransferase (HAT) and histone deacetylase (HDAC) are important for regulating gene expression

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