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However, it passes easily through cell membranes and when taken orally, NR reliably raises NAD+ levels

Janssens, G.E., et al., Healthy aging and muscle function are positively associated with NAD+ abundance in humans

While the nephroprotective effects of SGLT2i were initially derived from secondary endpoints of CV outcome trials (CVOTs), direct confirmation came from dedicated kidney focused trials: CREDENCE (Perkovic et al NEJM 2019| NephJC Summary), DAPA-CKD (Heerspink et al NEJM 2020| NephJC Summary) and finally EMPAKIDNEY (Herrington et al NEJM 2023| NephJC Summary)