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Non-responders exist even among ideal candidates

Side Effect Profiles Whether semaglutide comes in a pill or injection, the most common side effects are the same: Stomach pain Yellow skin or eyes Fever Sweating Dizziness Anxiety Nausea Bloating Vomiting Constipation Diarrhea Faster heartbeat Shakiness or weakness Headaches Blurred vision Fatigue Interestingly, oral and injectable options have about the same risk of adverse side effects

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The SURMOUNT-5 trial showed tirzepatide achieved 20.2% weight loss versus 13.7% for semaglutide