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19-23 Dosing and administration: All DPP-4 inhibitors currently approved for use in the U.S

The water addition is catalyzed by an enoyl-CoA hydratase activity, the second oxidation step is catalyzed by an NAD-dependent long-chain hydroxyacyl-CoA dehydrogenase activity (3-hydroxyacyl-CoA dehydrogenase activity), and finally the cleavage into an acyl-CoA and an acetyl-CoA is catalyzed by a thiolase activity

Second, consider the timing

Calcidiol, a major circulating form, is usually used for estimating vitamin D status, whereas calcitriol is the active metabolite for biological functions [97]