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Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

However, their mechanisms, applications, and potential side effects differ, including factors such as affecting blood sugar levels shaping how individuals and healthcare providers choose the best weight loss solution for personalized treatment plans

Cyanocobalamin This is an unnatural synthetic form of vitamin B12 that is created in a lab

The compound has not progressed through a drug-approval pathway in any major jurisdiction