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It also disrupts ER Ca 2+ pool homeostasis, triggering ERS, interfering with protein degradation, and leading to protein accumulation

Notably, in comparative assays measuring neurotrophic activity, Dihexa exhibited potency seven orders of magnitude greater than brain-derived neurotrophic factor (BDNF) in promoting new neuronal connections

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The GCL enzyme is a heterodimer formed by two subunits: the heavy subunit or glutamate cysteine ligase catalytic subunit (GCLC, 73 kDa) and the light subunit or glutamate cysteine ligase modulating subunit (GCLM, 30 kDa)