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3.1 Ceramides affects the lipid composition of the mitochondria membranes Mitochondrial membrane lipids are essential for several mitochondria processes such as membrane architecture, transport of proteins into the matrix, activity of respiratory proteins, mitochondrial fission and fusion, and contribution of lipids to endoplasmic reticulum related through contacts by the mitochondria-associated membranes (MAMs) (Bttinger et al., 2016

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For the purposes of clinical studies, as well as routine practice, the Neuropathy Disability Score (NDS) was developed (Table 3)