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[DOI] [PubMed] [Google Scholar] 14.Rolke R, et al

An additional benefit was that the only other lysine, at position 34, could be substituted with arginine resulting in a GLP-1 analog that could be used in a semi-recombinant process, where the peptide backbone was produced recombinantly and the fatty acid attached afterwards by a simple chemical reaction (42)

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En pacientes con obesidad a quienes se les recet semaglutida o liraglutida, descubrimos que la reduccin de peso a largo plazo variaba significativamente segn el agente activo del medicamento, la indicacin del tratamiento, la dosis y la persistencia con el medicamento, relata Hamlet Gasoyan , autor principal del estudio e investigador del Centro de Investigacin de Atencin Basada en el Valor de la Clnica Cleveland