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The differences in research results may be attributed to several aspects: (1) Researchers have different research purposes and design different research schemes

The International Diabetes Federation projected that the number of diabetes cases is expected to reach 643 million by 2030 and 783 million by 2045

In animal models, use of the choline TMA lyase inhibitor iodomethyl choline (IMC) increases bacterial cholesterol metabolite loss and decreases intestinal sterol transport protein Niemann-Pick C1-Like 1 (NPC1L1) expression, reshaping gut microbiota and reducing hepatic cholesterol accumulation, while upregulating CYP7A1 and other bile acid-related genes (Pathak et al., 2020)

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