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Retrospective cohort studies show that these agents do not increase the risk of IBD flares or gastrointestinal-specific adverse events compared to the general population ( Metabolic outcomes GLP-1RAs consistently yield significant weight loss and glycemic control in patients with IBD and comorbid obesity or diabetes

While it's not always visible, there are a few signs that may indicate your semaglutide has gone bad , including: Change in appearance: The liquid inside the pen or vial should be clear and colorless