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Chronic hypoxia promotes ceramide hydrolytic metabolism by activating the HIF-2/Acer2 signaling pathway, and thereby downregulates PP2A activity The above study found that hypoxia caused -syn hyperphosphorylation by inhibiting PP2A activity

J Allergy Clin Immunol 88(5):784792 Empedrad R, Darter AL, Earl HS, Gruchalla RS (2003) Nonirritating intradermal skin test concentrations for commonly prescribed antibiotics

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