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Alshehri, Umm Al Qura University, Saudi Arabia Marcello Agosta, University of Catania, Italy Updates Copyright 2025 Cominato, Resende, Bernardes, Rachid, Passone, Mattar, Neme, Souza, Santos, Franco and Damiani

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Conditional knockout of p65 in macrophages impairs GYY4137 protective effects against OA progression To examine the role of the NF-kB signaling in mediating GYY4137 protective effects on osteoarthritis progression in vivo, we generated p65 f/f LysM-CreER T2 conditional knockout mice as described in Fig