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Severe liver problems.Stop taking ORLISTAT and call your doctor right away if you have the following symptoms of liver problems: loss of appetite itchy skin yellowing of your skin or the white part of your eyes amber-colored urine light-colored bowel movements (stools) pain in the upper right portion of your stomach Kidney problems.Your doctor may do certain tests to check your kidney function during treatment with ORLISTAT

Like GLP-1, GIP is involved in metabolic signaling