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Conditions that can cause cobalamin deficiency include: Inflammatory bowel disease (IBD) Exocrine pancreatic insufficiency (EPI) Pancreatic cancer Chronic enteropathy Alimentary lymphoma Small intestinal dysbiosis Inherited selective cobalamin malabsorption Inherited selective cobalamin malabsorption, which is known as Imerslund-Grsbeck syndrome (IGS) in humans, makes a dog genetically predisposed to have difficulty absorbing cobalamin

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Raw reads were uploaded to the Galaxy server 80 and its instance at the University of Manchester ( QCed and trimmed using Trimmomatic 81 , then aligned to the mouse genome GRCm39 guided by the vM27.annotations from GENCODE 82 using HISAT2 aligner 83

As shown in Figure 1 B, the decrease in the cell viability induced by Mg 2+ treatment was significantly alleviated by Fer-1, which showed no significant alteration by the inhibitors of apoptosis, pyroptosis, and necroptosis