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10.1016/j.cell.2005.12.022 [DOI] [PubMed] [Google Scholar] Lodhi IJ, Semenkovich CF

The histidine residue in GHK-Cu coordinates the copper ion through its imidazole nitrogen, creating a stable five-membered chelate ring

This effect ultimately disrupts bile acid synthesis and promotes inflammatory responses, thereby accelerating the progression of gout ( Figure 4 )

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