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On the other hand, their pleiotropic actions, frequent involvement of the central nervous system, and context-dependent effects have historically rendered them unattractive as therapeutic targets

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These findings suggest that a reduction in the antioxidant properties of the aqueous humor is a common feature in IOP-dependent and IOP-independent glaucoma patients

Though not yet proven, limited evidence suggests an increased cancer risk in those with higher-than-normal B12 levels