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HaarhuisJEDay-WalshPShehataESavvaGMPeckBPhiloMet al

SGLT2is as Foundational Therapy in Adults with CKD There was a clear consensus that SGLT2is should be positioned as foundational therapy in adults with CKD and T2D, independent of BMI and in particular in the presence of HF, given their consistent kidney protective benefits and well-established mechanisms of action [20,21,22]

Upon GLP-1 binding to its receptor GLP1R on pancreatic beta cells, a signaling cascade is initiated, leading to the activation of adenylyl cyclase and the production of cAMP), which activates protein kinase A (PKA) enhancing insulin gene transcription and insulin secretion 81

Dai GL, et al