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Epidemiologically, metformin administration has been associated with a reduced incidence, recurrence and mortality of pancreatic cancer in diabetic patients, 268,481 although a beneficial effect was not observed in all studies, 482 especially in patients with advanced PDAC

Holland & Barrett will offer nutritional advice to those on weight loss journeys, including those on GLP-1 drugs, who are more likely to experience nutritional deficiencies, with research showing that roughly one in 10 have at least one new nutritional deficiency after taking the drug for six months

Treatment should only be continued if there is a beneficial metabolic response (reduction of at least 11 mmol/mol [1%] in HbA1c and weight loss of at least 3% of initial body weight in 6 months)

The most dramatic changes typically occur between weeks 12 and 24 (months 3 to 6), when you are at or approaching the full 2.4 mg dose and the cumulative caloric deficit has produced visible body changes