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Pharmacokinetically, metformin is absorbed primarily in the small intestine, with a bioavailability of approximately 50%60% under fasting conditions (Jones et al., 2022)

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To help with explanations, a brief summary of the methionine cycle, transsulfuration pathway, and connections to the folate cycle and Betaine (GB) pathway is provided in the next paragraph, and a schematic representation in figure 1