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Five half-lives (roughly 5 weeks) covers near-complete elimination, and the 2-month buffer adds a safety margin for patients who are actively attempting conception

While NAC (N-acetylcysteine) is sometimes used to boost glutathione, people with genetic polymorphisms in cysteine metabolism do not effectively convert it into glutathione

The study was approved by the Regional Ethics Committee in Stockholm, Sweden

The practical implication is clear: if lowdose metformin begins its work in the brain, future therapies may achieve control with lower exposure or target similar neural circuits more precisely, a direction suggested by the Science Advances research