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This reduction in GSH wasnt linked to blood sugar levels or HbA1c (a marker for long-term blood sugar control)

While the long-term consequences of GLP-1R agonism are now emerging, similar studies will be required for glucagon, particularly in the context of simultaneous GLP-1R agonism

The Action to Control Cardiovascular Risk in Diabetes trial and the Veterans Affairs Diabetes Trial have shown that while intensive glycemic control may slow the progression of neuropathy, it does not significantly prevent its onset

This includes trials of drug combinations such as Novo Nordisks CagriSema that combines semaglutide with investigational drug cagrilintide to improve efficacy